Course Info: NS-0344
| Course | NS-0344 Enzymes |
| Long Title | Enzymes |
| Term | 2016S |
| Note(s) |
Textbook information |
| Meeting Info | Cole Science Center 101 on M,F from 1:00-2:20 |
| Faculty | Rayane Moreira |
| Capacity | 16 |
| Available | 11 |
| Waitlist | 0 |
| Distribution(s) | |
| Cumulative Skill(s) | Quantitative Skills Independent Work |
| Additional Info | In this course students are generally expected to spend at least 6 to 8 hours a week of preparation and work outside of class time. |
| Description | In this course we explored the fundamentals of catalysis and how they manifest in enzymatic systems. We used nature's "simplest" catalyst, the proton, to examine the physical principles of catalysis, followed by iron as a "simple" redox catalyst. These two models were used to address the similarities and differences between homogeneous chemical catalysis and enzymes, including their substrate specificity, regio- and stereoselectivity, and enormous rate accelerations. After a unit on enzyme kinetics, we examined some particularly important enzymes and enzymatic systems. We started with some well-studied systems, such as the serine proteases, alcohol dehyrogenase, and cytochrome P450, and compared these with some enzymes and enzyme complexes of particular biological and environmental interest, such as Methane Monooxygenase, Rubisco, Photosystem II, and ATP Synthase. Prerequisite: Organic Chemistry I. |